Thalamic-caudal zona incerta deep brain stimulation for refractory orthostatic tremor: a report of 3 cases

Resumen:
This is the site of the active contacts delivering the most effective stimulation in the current patients. The efficacy of thalamic¿subthalamic DBS despite the absence of any change in leg tremor, together with the evidence of coupled oscillatory activity in the ViM, suggests that cerebellar input to the thalamus (ViM) may be part of this feedback loop. Although the observation period in these reported cases was short, based on these and previous cases, further long¿term data from controlled clinical trials are needed to examine the efficacy of this approach in OT.