Detalle Publicación

ARTÍCULO

Brain oscillations and Parkinson disease

Autores: Foffani, G. (Autor de correspondencia); Alegre Esteban, Manuel (Autor de correspondencia)
Título de la revista: HANDBOOK OF CLINICAL NEUROLOGY
ISSN: 0072-9752
Volumen: 184
Páginas: 259 - 271
Fecha de publicación: 2022
Resumen:
Brain oscillations have been associated with Parkinson's disease (PD) for a long time mainly due to the fundamental oscillatory nature of parkinsonian rest tremor. Over the years, this association has been extended to frequencies well above that of tremor, largely owing to the opportunities offered by deep brain stimulation (DBS) to record electrical activity directly from the patients' basal ganglia. This chapter reviews the results of research on brain oscillations in PD focusing on theta (4-7Hz), beta (13-35Hz), gamma (70-80Hz) and high-frequency oscillations (200-400Hz). For each of these oscillations, we describe localization and interaction with brain structures and between frequencies, changes due to dopamine intake, task-related modulation, and clinical relevance. The study of brain oscillations will also help to dissect the mechanisms of action of DBS. Overall, the chapter tentatively depicts PD in terms of "oscillopathy."