RROL lncRNA role in multiple myeloma

Resumen:
In this issue of Blood, Morelli et al1 show that the novel long noncoding RNA (lncRNA) named RROL (RNA Regulator of Lipogenesis), derived from the MIR17HG gene, acts as a chromatin scaffold for protein interaction that results in the growth of multiple myeloma cells. Their study shows that RROL inhibition exhibits a potent antimyeloma activity both in vitro and in different in vivo models, suggesting a therapeutic potential.