Detalle Publicación

ARTÍCULO

Combined PI3K/Akt and Smad2 activation promotes corneal endothelial cell proliferation

Autores: Sabater Gozalvo, Alfonso Luis; Andreu Oltra, Enrique José; García Guzmán, María del Rosario; López Martínez, T.; Abizanda Sarasa, Gloria María; Pérez, V. L.; Moreno Montañés, Javier; Prosper Cardoso, Felipe
Título de la revista: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE
ISSN: 0146-0404
Volumen: 58
Número: 2
Páginas: 745-754
Fecha de publicación: 2017
Resumen:
We demonstrated that the combined activation of PI3K/Akt and Smad2 results in in vitro expansion of phenotypic and functional CEC. Expanded cells were able to contribute to restoration of corneal endothelium in a rabbit model. These findings may represent a new therapeutic approach for treating corneal endothelial diseases
DOI: https://doi.org/10.1167/iovs.16-20817
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