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Guillermo Martínez de Tejada de Garaizábal

Microbiology and Parasitology
School of Medicine University of Navarra
Lines of research
Mechanisms of bacterial resistance to antibiotics. Bacterial biofilms, antimicrobial and anti-endotoxic peptides. Application to the potentiation of antibiotics against multiresistant bacteria.

The Full Professor Guillermo Martínez de Tejada is the Deputy Director of the department of Microbiology and Parasitology of the School of Medicine of the University of Navarra. Since 1988 his research focused on the mechanisms of pathogenicity of Gram-negative bacteria Brucella, Bordetella and Pseudomonas. In addition, in the last 15 years he is investigating how to neutralize antibiotic resistance mechanisms by antimicrobial peptides combining bactericidal and antibiotic-enhancing activity. Using a wide variety of animal models, his group demonstrated that these new drugs sensitize multidrug-resistant bacteria to antibiotics and confer effective protection against sepsis and endotoxic shock. At partnership with bioengineers, he is taking advantage of the potent affinity these compounds have for bacterial endotoxin to develop microchip-based biosensors for the detection and quantification of pyrogens. Dr. Martínez de Tejada has been the researcher lead on 11 competitive projects with peer review and has participated as partner scientist in 8 other projects, including 2 funded by the European Union and 1 by the U.S. National Institutes of Health. He collaborated as researcher in 4 research contracts with companies, 3 of them as researcher lead. Dr. Martínez de Tejada is co-author of 71 original articles and reviews, as well as 8 book chapters. He has directed 9 doctoral thesis , 3 final papers Master's Degree and 9 final papers Degree. Finally, he is the co-inventor of 3 patents and has an H index of 27 (Google Scholar) and 23 (Web of Science).