AGATA Alliance in Advanced Gonomics for the development of Personalized Therapies in Navarra. Funding Entity: Government of Navarra. researcher Funding Entity: Estíbaliz Alegre. Duration: 2020-2022

Identification of immunomodulatory targets for the development of neuroprotective treatments for Parkinson's disease. Funding entity: Fundación Gangoiti. researcher principal: María S. Aymerich. 2021

NGS assays for the determination of mutations in patients with LANL. subject of contract: Contract of research. business/Funding administration: PETHEMA. researcher manager : Mª José Calasanz. Duration: 2017-2020.

Analysis, development and validation of NGS assays for the determination of ABL1 mutations in patients with CML. subject Contract: Contract of research. business/Funding administration: INCYTE. researcher manager : Mª José Calasanz. Duration: 2017-2020.

Genomic study for the personalisation of the diagnosis and treatment of patients with chronic heart failure and chronic kidney disease (Personalised Cardio-renal Medicine in Navarra) (MINERVA).
Funded by: Government of Navarra, 2018 GN Strategic Projects of research and development. researcher Principal: Juna José Gaviera. researcher of the department: Nerea Varo. Duration 2018-2020.

Clinical utility in prostate carcinoma of the quantification of cytokines in exosomes.
Funded by: Fundavión José Luis Castaño. Researchers: Estíbaliz Alegre, Mónica Macías. Duration 2018-2019.

Pathophysiological characterisation of NADPH oxidase isoform 5 (Nox5) in obesity and its impact on cardiovascular disease.
Funded by: Ministry of Economics and Competitiveness (MINECO), ref. SAF2016-79151-R. researcher manager : Guillermo Zalba. Duration: 2017-2019.

Use of next-generation molecular strategies for the identification of new therapeutic targets and prognostic markers in poorly characterised types of lung carcinoma.
Funded by: association Española contra el Cáncer (AECC GCB14-2170). researcher manager : Luis Montuenga Badía. Participating entities: research center Médica Aplicada-CIMA, Institut d' Investigació Biomèdica de Bellvitge-IDIBELL, Hospital Universitari Vall d'Hebron. Duration: 2014- 2019.

Validation of GPR41 in AD.
subject of contract: Technology Service. business/Funding administration: Laboratorios SERVIER. researcher manager : Alberto Pérez Mediavilla. Duration: 2017-2018.

Technical standardisation of NGS in the diagnosis of myelodysplastic syndromes and chronic myelomonocytic leukaemia based on NGS guidelines in MDS.
Funded by: group Spanish Myelodysplastic Syndromes (GESMD). researcher manager : Mª José Calasanz, Francesc Solé and Esperanza Such. Duration: 2017-2018.

Study of the interaction of adipokines and myokines in the development of obesity and associated comorbidities.
Funded by: high school de Salud Carlos III (FIS) FIS PI16/00221. researcher manager : Amaia Rodríguez Murueta-Goyena. Duration: 2016-2018.

Targeting the complement cascade: a novel therapeutic strategy for metastatic melanoma.
Funded by: National Health and Medical Research Council (Australia). researcher manager : Barbara Rolfe. Co-Principal Investigators: Trent Woodruff, Glen Boyle, Ruben Pio. Duration: 2016-2018.

Obtaining bioactives for the prevention of obesity and metabolic syndrome by bioguided fractionation of natural extracts (OBEBACS).
Funded by: department de development Económico, Gobierno de Navarra. researcher manager : Carlos Javier González Navarro. Participating entities: project collaborative research center in Nutrition University of Navarra (CIN-UNAV) and National Centre for Food Technology and Safety (CNTA). Duration: 2016-2018.

The primary cilium as a clinical prognostic factor in medulloblastomas.
Funded by: Fundación Universitaria de Navarra. researcher manager : Javier Sáez Castresana. Duration: 2015-2018.

Study of the SET oncoprotein as a therapeutic target in acute myeloid leukaemia. Towards a personalised treatment using a combination of PP2A activators and tyrosine kinase inhibitors in patients with SET overexpression.
Funded by: department de Salud del Gobierno de Navarra (29/2015). Participating entities: department de Biochemistry and Genetics, University of Navarra. Clínica Universidad de Navarra. Complejo Hospitalario de Navarra. researcher manager : Mª Dolores Odero. Duration: 2015-2017

development of a new tool for the search for more effective anti-tumour treatments using the zebrafish animal model .
Funded by: department de Industria del Gobierno de Navarra (0011-1365-2016-000294). researcher manager : María Dolores Odero. Duration: 2016-2017.

Effect of a programme based on the hypocaloric Mediterranean per diem expenses and promotion of physical activity in children with obesity and risk of diabetes: genetic and epigenetic study.
Funded by: association Española de Pediatría and Laboratorios Ordesa. researcher manager : Mª Cristina Azcona. Duration: 2016-2017.

development of a massive sequencing guide in myelodysplastic syndromes and chronic myelomonocytic leukaemia.
Funded by: group Spanish Myelodysplastic Syndromes (GESMD). researcher manager : Dr. Esperanza Such. Duration: 2016-2017.

Chemokine receptor inhibitors in models of lung cancer.
subject of contract: Contract of research. business/Funding administration: Dompé Farmaceuti. researcher manager : Rubén Pío. Duration: November 2016 - April 2017.

The primary cilium as a clinical prognostic factor in medulloblastomas.
Funded by: Fundación Universitaria de Navarra. researcher manager : Javier Sáez Castresana. Duration: 2015-2018.

Identification and validation of diagnostic markers and therapeutic targets in lung cancer related to the activation of the complement system.
Funded by: Ministry of Health and Consumer Affairs (PI14/01686). researcher manager : Rubén Pío. Duration: 2015-2017.

Novel gene expression based prognostic markers: role in normal haematopoiesis and MDS disease pathogenesis .
Funded by: Wordwide Cancer Research Project. UK. researcher manager : Dr. Pellagatti. Duration: 2015-2017.

finding and characterisation of small molecule activators of the tumour suppressor protein PP2A for the treatment of acute myeloid leukaemia. Funded by: Ministry of Economics and Competitiveness. high school de Salud Carlos III (PI14/02073). researcher manager María D. Odero. Duration: 2015-2017

Mechanism of neuroprotection through the modulation of endogenous cannabinoids in Parkinson's disease. project integrated in the State Plan research and development+I 2013-2016 and co-financed by the ISCIII-Subdirectorate General of assessment and Promotion of the research and the European Regional Fund development (ERDF). researcher manager : Mª Soledad Aymerich Soler.

Study of tumour exosomes as inducers of myeloid suppressor cells and messenger transporters of immunosuppressive molecules.
Funded by the high school de Salud Carlos III, Fondo de research Sanitaria. researcher manager : Álvaro González. Duration from 2015 to 2017. 

Trafficking of T lymphocytes report and effectors through tumour-associated lymphatic endothelium: optimisation of immunotherapy .
Funded by the Fondo de research Sanitaria (FIS). Ministry of Science and Innovation. Ref.: PI13/02313. researcher manager : Ana Rouzaut. From January 2014 to December 2016. development This project is co-funded by the European Regional Fund (ERDF): "A way of doing Europe".

New mechanisms of oxidative stress in vascular pathology: role of NADPH oxidase 5.
Funded by: Ministry of Economics and Competitiveness (MINECO), ref. SAF2013-49088-R. researcher manager : Guillermo Zalba. Duration: 2014-2017.

Mechanisms involved in the genesis of chronic myeloproliferative neoplasms with CALR mutations: development of an experimental model in Caenorhabditis elegans .
Funded by PIUNA. researcher manager : José Luis Vizmanos. Duration from 2014 to 2017.

Stress response in fibrotic liver: role of non-phagocytic NOX variants and physiological inducers of reticulum stress .
Funded by PIUNA. researcher manager : María Iraburu. Duration from 2014 to 2017. 

Immunostimulatory Agonist antibodies for Cancer Therapy (IACT Consortium) .
Funded by: FP7-HEALTH European Commission. researcher manager : Ignacio Melero. Duration: 2013-2017

An investigation of the molecular pathogenesis and pathophysiology of MDS, including the 5q- syndrome: identification of new therapeutic targets .
Funded by: Leukaemia & Lymphoma Research Specialist Programme grant UK. researcher manager : Dr Jacqueline Boultwood. Duration: 2013-2017

Analysis, development and validation of FISH assays for the determination of 5q deletion in patients with myelodysplastic syndromes .
Funded by group Celgene España. researcher manager : Mª José Calasanz. Duration: 2007-2017

RADical reduction of OXidative stress in cardiovascular diseases (RADOX).
Funded by: 7th Framework Programme-PEOPLE-2012-Initial Training Network (ref. 316738). researcher manager : Guillermo Zalba (coordinator An Moens). From January 2013 to December 2016.

COST ACTION BM1203 (EU-ROS).
Funded by European Science Foundation, European Union 7th Framework Programme. researcher manager : European Consortium. Participating researchers: Guillermo Zalba. From January 2012 to December 2016.

Molecular mechanisms in the development and progression of leukaemias and lymphomas .
Funded by: network Temática de research Cooperativa en Cáncer (RTICC) del high school de Salud Carlos III. Call for RETICS 2012 (Num. transcript: RD12/0036/0063).researcher manager : María Dolores Odero de Dios. From January 2012 to December 2015.

Contribution of tumour stem cells and tumour border cells to the molecular diagnosis and prognosis of glioblastoma.
Funded by Fundación Universitaria de Navarra (PIUNA). researcher manager : Javier Sáez Castresana. September 2012 to August 2015. Researchers: Miguel Angel Idoate, Gabriel Gallo, Javier de la Rosa, Beatriz Vera, Javier Sáez Castresana.

Performance of the Contour XT blood glucose testing system .
Contract with business: BAYER HISPANIA. researcher manager : Nerea Varo. From 29 May 2013 to 30 October 2013. Participating researchers: Nerea Varo and Sara Fernández.

Role of the complement system in tumour progression and identification of molecular markers related to its activation .
Funded by the high school de Salud Carlos III. FIS. researcher principal: Rubén Pío Osés. From January 2012 to December 2014.

project Vitamin D:1.-Study of the association of coronary calcium and epicardial fat volume in patients at high cardiovascular risk. Vitamin D deficiency as a cardiovascular risk factor. 2. Study of the usefulness of bone remodelling markers in osteoporosis associated with chronic obstructive pulmonary disease (COPD). Study of vascular calcification and inflammation in chronic kidney disease. Contract with business: Roche Diagnostics. researcher manager : Nerea Varo. From 2012 to 2014

Study of protein phosphatase PP2A as a therapeutic target in acute myeloid leukaemia.
Funded by the department de Salud del Gobierno de Navarra (78/2012) researcher principal. Mª Dolores Odero. January 2012 to December 2014.

Study of protein phosphatase PP2A in the transformation of acute myeloid leukaemia and its possible role as a therapeutic target in cancer .
Funded by the Ministry of Science and Innovation (PI11/02443). researcher principal. Mª Dolores Odero. January 2012 to December 2014.

Search for tumour markers associated with circulating exosomes in melanoma patients.
Funded by the high school de salud Carlos III (FIS). researcher principal: Álvaro González. January 2012 to December 2014. Researchers: Alvaro González, Estíbaliz Alegre, Nerea Varo.

Molecular mechanisms of pathogenesis of chronic myeloproliferative neoplasms and related diseases.
Funding entity: PIUNA. researcher manager : José Luis Vizmanos. From September 2011 to December 2014.

Nutrition: epigenetic regulation of Caveolin 1 expression in the process of adipogenesis, relationship with insulin signalling. Influence of inflammation, hyperglycaemia and hypoxia.
Funded by PIUNA. researcher manager : Fermín Milagro Yoldi. From 27 November 2012 to 31 August 2013. Researchers: Fermín Milagro, Carlos De Miguel, Sara Palacios, Maider Varela.

New molecular and cellular mechanisms of oxidative stress involved in cardivascular alterations in patients with metabolic syndrome .
Funded by the Spanish Ministry of Science and Innovation (SAF2010-20367). researcher principal: Guillermo Zalba. Researchers: Álvaro Pejenaute. January 2011 to December 2013. Extended during 2014.

In vivo identification of the types of circulating HLA-G molecules. Implications for their analysis in tumour pathology.
Funding Entity: high school de Salud Carlos III (FIS). researcher Principal Investigator: Álvaro González Hernández. Researchers: Alegre Martínez Estíbaliz, Arroyo Beamonte Ainhoa, Echeveste José Ignacio, Pérez Gracia Jose Luis. January 2011 to December 2013.

Regulation of liver fibrosis: identification of potential therapeutic targets.
PIUNA. 1 September 2010 to 31 August 2013. researcher principal: María Iraburu. Team: María Iraburu, Mª Jesús López Zabalza, Juan José Martínez Irujo, Marina Ruiz de Galarreta, Antonia García Garzón, María Martínez Azcona, Teresa Mòdol Betriu, José Manuel Zozaya Urmeneta.

Involvement of the CCR5/MIP1alpha axis in the establishment of lymph node metastasis in lung carcinoma. Role of the TGFb cytokine from the primary niche. PI10/02131
Funding Entity: Fondo de research Sanitaria (FIS). Ministry of Science and Innovation Duration January 2011-December 2013. researcher principal: Ana Rouzaut. Team: Ana Rouzaut, Xabier Morales.

Cost-effectiveness study of bone remodelling markers vs. densitometry in osteoporosis .
Contract with business: Roche Diagnostics. researcher manager : Ignacio Monreal. From 2010 to 2012.

Identification of genomic markers with prognostic value in patients diagnosed with early stage lung carcinoma using microarrays of single nucleotide polymorphisms (SNPs).
researcher principal: María Isabel Zudaire. Team researcher: Rubén Pío, Alberto Orta, Alfonso Gúrpide, David Blanco, Cristina Sainz. Funding entity: department de Salud del Gobierno de Navarra. Duration: 2010-2012

Leticia Colyn Pedrero. "Dual targeting of histone methyltransferase G9a and DNMT1 for the treatment of experimental cholangiocarcinoma". Directors: Dr. Matías Ávila Zaragozá and Dr. María Iraburu Elizalde. Date: 11 March 2022.

Adriana Cortés Jiménez. "Role of NADPH Oxidase 5 (NOX5) in cardiovascular physiopathology: Relevance of NOX5 in the mechanisms associated with endothelial dysfunction. DirectorBy: Guillermo Zalba Goñi. Date: 13 December 2021

Alejandro Urdiciain Ezpeleta. "The role of histone deacetylase 6 in the development of gioblastoma". DirectorFrancisco Javier Sáez Castresana. Date: 11 December 2020.

Alba Yangüas Andrés. "Strategies for the study and optimisation of tumour immunotherapy in experimental models of melanoma and breast carninoma. Director: Ana Rouzaut Subirá. Date: 7 October 2020.

Miguel Ángel Abellanas Sánchez."Immunosuppressive mechanisms of midbrain microglia in models of neuroinflammation and neurological damage. Director: María Soledad Aymerich Soler. Date: 30 September 2020.

Amaia Navarro Corcuera. "Role of AGAP2 in Liver pathophysiology". Directors: María Iraburu Elizalde, Eduardo Ansorena Artieda and Cristina Montiel Duarte. Date: 23 November 2018.

Aitor Andueza Lizarra."Expression and functional relevance of NADPH oxidase 5 in Eastern cells". DirectorBy: Juan José Martínez Irujo. Date: 26 October 2018.

David Navarro Herrera. "development, validation and implementation of a model in C. elegans for the identification of bioactive compounds in obesity-related processes". DirectorJosé Luis Vizmanos Pérez. Date: 14 December 2017

Estefanía Rojo Bustamante. "Characterization of the neuroprotective effect of the monoacylglycerol lipase inhibition using in vitro and in vivo models of Parkinson's disease". Director: Marisol Aymerich Soler. Date: 13 December 2017

Laura Eder Azanza. "Analysis of new genetic alterations in BCR-ABL1 negative myeloproliferative neoplasms. development of an experimental model of subject 1 and subject 2 mutations in CALR in Caernohabditis elegans". DirectorJosé Luis Vizmanos Pérez. Date: 1 December 2017.

Álvaro Pejenaute Martínez de Lizarrondo: "Potential role of NADPH oxidase 5 (NOX5) in arterial hypertension: Development of a new animal mode and a recombinant adenovirus". DirectorBy: Guillermo Zalba. Date: 24 November 2017.

Ricardo García López: "The role of Tox3 and histone deacetylase inhibitors in embryonal tumours". Directors: Javier Sáez Castresana and Xin Fan (University of Michigan). Date: 31 July 2017.

Beatriz Vera Cano: "Oncolytic adenoviruses as a therapeutic strategy for central nervous system tumours". Directors Marta María Alonso Roldán and Javier Sáez Castresana. Date: 13 March 2017.

Javier de la Rosa Fernández-Pacheco: Synergistic study of the drugs APR-246, DZ-Nep, panobinostat and temozolamide as pharmacological treatment in glioblastoma. Directors: Javier Sáez Castresana and Miguel Ángel IdoateGastearena Date 11 November 2016.

Maider Varela Guruceaga: Effect of hypoxia on caveolin-1 expression, caveolae structure and insulinsignaling. Directors: Carlos de Miguel Vázquez and Fermín Milagro Yoldi. Date: 12 December 2016

Carmen Pérez de Ciriza Villacampa. Evaluation of circulating osteoprotegerin as a new biomarker in the metabolic syndrome: cardiovascular risk assessment, analytical factors and circulating sources.
Director: Nerea Varo. area de Biochemistry

Marina Ruiz de Galarreta Martínez. Regulation of liver fibrogenesis by UPR and COMP protein.
Director: Maria Iraburu. area of Biochemistry .

Sara Palacios Ortega. Regulation of the expression and activation of Caveolin-1 during adipogenesis, and its relationship with insulin signalling. Effect of TNF-alpha and glucose.
Directors: Carlos de Miguel and Fermín Milagro.

Marta Fernández Mercado. Characterisation Genetics of patients with myelodysplastic syndrome and normal karyotype. Prevalence and functional analysis of ASXL1 gene mutations. doctorate European.
Directors: Mª Dolores Odero de Dios and Jacqueline Boultwood (University of Oxford). area of Genetics.

Mikhail Shugay. Computational analysis of gene fusions in cancer.
DirectorFrancisco Javier Novo Villaverde. area de Genetics.

Xabier Cortés Lavaud. Contribution of the GATA2 transcription factor to the development and progression of myeloid malignancies.
Director: Mª Dolores Odero de Dios. area de Genetics.

Marta Zamarbide González. Study of the neurodegenerative mechanisms related to endoplasmic reticulum stress and free fatty acid receptors in Alzheimer's disease.
Directors: Alberto Pérez Mediavilla and Rafael Franco Fernández.

Diana Fernández Suárez. Anatomical-functional study of the external globus pallidus and assessment of the neuroprotective effect of the endocannabinoid system in animal models of Parkinson's disease.
Directors: Marisol Aymerich Soler and Rafael Franco. area of Biochemistry and Molecular Biology.

Iñigo Ortiz de Mendibil Ayuso. Strategy for the identification and functional characterisation of new chromosomal translocations in cancer.
DirectorFrancisco Javier Novo Villaverde. area of Genetics.

Laura Montero Barreras. Oxidative stress and telomere shortening in patients with metabolic syndrome: role of NADPH oxidase.
DirectorGuillermo Zalba Goñi. area of Biochemistry and Molecular Biology.

Elisa Mª Salas Cintora. Genetic mechanisms of activation of the JAK2/STAT5 signal transduction pathway in haematological malignancies: identification and characterisation of new target genes.
DirectorFrancisco Javier Novo Villaverde. area de Genetics.

Idoia Blanco Luquin. Analysis of the p53/Mdm2/p14ARF pathway in neuroblastoma and its relationship with chemotherapy.
Directors: Ignacio Encío Martínez and Paula Lázcoz Ripoll (UPNA) and Javier Sáez Castresana. area of Biochemistry and Molecular Biology.

Ignacio Erquiaga Martínez. Analysis of cytokine receptors in BCR-ABL1 negative chronic myeloproliferative neoplasms.
DirectorJosé Luis Vizmanos Pérez. area de Genetics.

Álvaro Teijeira Sánchez Dendritic cell trafficking through the lymphatic endothelium under inflammation.
Directors: Ana Rouzaut Subirá and Ignacio Melero Bermejo. area Biochemistry and Molecular Biology.

Elisabeth Salvo Brugarolas Study of cellular and molecular mechanisms involved in NSCLC cell migration induced by TGF-beta.
Director: Ana Rouzaut Subirá. area Biochemistry and Molecular Biology.

Begoña Euba Rementería. Epigenetic analysis of the PIAS family genes and detection of mutations in the TET2 gene in myeloproliferative neoplasms.
Director: Marina García Delgado. area de Genetics.

Mª Pilar Gil Sánchez. Role of FAK in the acantholysis of pemphigus vulgaris in a murine model .
Directors: Agustín España Alonso (CUN) and Mª Jesús López Zabalza. area of Biochemistry and Molecular Biology.

Miren Maicas Irigaray. Mechanism of expression regulation and functional analysis of the EVI1 gene promoter. award Extraordinary doctorate.
Director: Mª Dolores Odero de Dios. area of Genetics.

Mikel Gurrea Rubio. Inhibition of Histone Deacetylase 4 reduces glioblastoma tumour growth in vivo: the role of deacetylases inhibitors and Notch signaling pathway in the treatment of glioblastomas.
Directors: Javier Sáez Castresana and Xing Fan (University of Michigan, Ann Arbor, MI, USA). area de Genetics.

Paula Aranaz Oroz. Genetic mechanisms of activation of signal transduction pathways in BCR-ABL1-negative chronic myeloproliferative neoplasms.
DirectorJosé Luis Vizmanos Pérez. area from Genetics.

Paula Valentina Schiapparelli Rodríguez. Role of Sonic Hedghog inhibition and characterization of stemness gene expression in neuroblastoma and Ewing sarcoma/PNET. doctorate European.
Directors: Javier Sáez Castresana and Paula Lázcoz Ripoll (Public University of Navarra). area de Genetics.

Elena Arriazu Ruiz. Characterisation of the response of hepatic stellate cells to amino acid deficiency.
Director: María Iraburu Elizalde. area of Biochemistry and Molecular Biology.

Ion Cristóbal Yoldi. Role of protein phosphatase 2A (PP2A) and its endogenous inhibitor SET in the development of acute myeloid leukaemia. award Extraordinary doctorate.
Director: Mª Dolores Odero de Dios. area of Genetics.

Jana Balbuena Delgado. Implication of Side Population tumour stem cells and hypoxia in drug resistance in astrocytoma cell lines.
Directors: Javier Sáez Castresana and Jordi Petriz (Hospital Vall d'Hebron, Barcelona). area de Genetics.

Natalia Suárez Fuentetaja. programs of study on the function of dendritic cells and their application in cancer immunotherapy.
DirectorÁlvaro González Hernández. area of Biochemistry and Molecular Biology.

Erik Wolfgang Oliemuller García. Function of collapsin response mediator protein-2 (CRMP-2) in non-small cell lung cancer.
Director: Ana Rouzaut Subirá. area of Biochemistry and Molecular Biology.

Alicia Zuazo Pérez. New angiogenesis inhibitors that exploit tumour hypoxia for therapy.
Directors: María Font Arellano and Juan José Martínez Irujo. area of Biochemistry and Molecular Biology.

Leticia Corrales Pecino. Complement activation in non-small cell lung cancer and its effects on tumour progression.
DirectorRubén Pío Osés. area of Biochemistry and Molecular Biology.

Marta Larráyoz Ilundáin. Functional relevance of VEGF-A and its receptors in lung cancer.
Directors: Jackeline Agorreta Arrazubi (CIMA) and Rubén Pío Osés. area of Biochemistry and Molecular Biology.

Maider Prétel Irazábal. Role of HER isoforms and mTOR in the acantholysis of pemphigus vulgaris in a murine model .
Directors: Mª Jesús López Zabalza and Agustín España Alonso (CUN). area of Biochemistry and Molecular Biology.

Cristina Ormazábal Goicoechea. Analysis of alterations in protein-coding genes with tyrosine kinase activity of the PDGFR and JAK families in BCR-ABL1-negative chronic myeloproliferative neoplasms.
DirectorJosé Luis Vizmanos Pérez. area de Genetics.

Teresa Mòdol Betriu. Effects of inflammatory mediators on monocytes and hepatic stellate cells.
Director: Mª Jesús López Zabalza. area of Biochemistry and Molecular Biology.

Carmen Vicente Vázquez. Role of the transcription factors GATA2 and MYB in acute myeloid leukaemia. doctorate European.
Director: Mª Dolores Odero de Dios. area de Genetics.

Ana Gómez Ruiz. Caveolin expression in skeletal muscle and adipocytes of white adipose tissue from rats fed with a high-fat hypercaloric per diem expenses . Relationship with insulin signalling.
Directors: Carlos de Miguel Vázquez and Fermín Milagro Yoldi. area of Biochemistry and Molecular Biology.

Patricia Restituto Aranguíbel. Study of the CD40/CD40L dyad and its modulation by adiponectin in metabolic syndrome.
Director: Nerea Varo Cenarruzabeitia. area of Biochemistry and Molecular Biology.

Elena Ansó Monclús. Effect on lymphatic endothelium of tumour hypoxia and inhibition of VEGF production by flavonoids.
DirectorJuan José Martínez Irujo. area of Biochemistry and Molecular Biology.

Monica Enguita Germán. Genetics and biology of medulloblastoma and PNET cell lines: role of CD133 brain tumour stem cell marker. doctorate europeo.
DirectorJavier Sáez Castresana. area de Genetics.

Ángel Díaz Lagares. Study of the action of nitric oxide on the HLA-G molecule and its ILT2 and ILT4 receptors.
DirectorÁlvaro González Hernández. area of Biochemistry and Molecular Biology.

Iria Vázquez Urio. Mechanisms of overexpression of the EVI1 gene (3q26) and its role in the leukemic transformation of patients with acute myeloid leukaemia. doctorate European.
Director: Mª Dolores Odero de Dios. area de Genetics.

Elisa Garbayo Atienza. design of polymeric vectors for the controlled release of GDNF in animal models of Parkinson's disease. Therapeutic perspectives.
Directors: Marisol Aymerich Soler and Mª José Blanco Prieto. area of Biochemistry and Molecular Biology.

Aiala Lorente Trigos. Epigenetic inactivation of tumour suppressor genes in astrocytomas. doctorate europeo.
DirectorJavier Sáez Castresana. area of Genetics.

Mónica Pérez Manso. Brain circuits involved in Parkinson's disease: thalamo-striatal pathway and expression of vesicular glutamate transporters.
Directors: Marisol Aymerich Soler and José Luis Lanciego Pérez. area of Biochemistry and Molecular Biology.

Estíbaliz Alegre Martínez. Study of molecules related to immunological tolerance HLA-G and indolamine 2,3-dioxygenase during pregnancy.
DirectorÁlvaro González Hernández. area of Biochemistry and Molecular Biology.

Miren Marquina Iñarrairaegui. Role of nitric oxide synthase in the acantholysis of Pemphigus vulgaris in a murine model .
Directors: Mª Jesús López Zabalza and Agustín España Alonso (CUN). area of Biochemistry and Molecular Biology.

Eva Martínez García. Study of the effect of repetitive exhibition to acute doses of nicotine on human bronchial epithelium cells.
Director: Ana Rouzaut Subirá. area of Biochemistry and Molecular Biology.

Mª Pilar Pérez de Obanos Martell. Regulation of the fibrogenic activity of hepatic stellate cells by leucine.
Director: María Iraburu Elizalde. area of Biochemistry and Molecular Biology.

Marta Irigoyen Goñi. Hypoxic microenvironment in tumours: evaluation of its influence on lymphangiogenesis processes.
Director. Ana Rouzaut Subirá. area of Biochemistry and Molecular Biology.

Daniel Ajona Martínez-Polo. Factor H expression in lung cancer and its protective role against complement system activation.
DirectorRubén Pío Osés. area de Biochemistry and Molecular Biology.

Borja Sáez Ochoa. Molecular cytogenetic characterization of chromosomal changes in Multiple Lyeloma. New insights into pathogenesis and diagnosis. doctorate europeo.
Directors: Reiner Siebert (Instituts für Humangenetik, Universitätsklinikums Schleswig-Holstein, Kiel) and Mª José Calasanz Abínzano. area de Genetics.

Zafira Castaño Corsino. Function of alpha CP-4 in lung carcinogenesis. assessment of its possible role as a tumour suppressor gene.
DirectorRubén Pío Osés. area of Biochemistry and Molecular Biology.

Lorena Fontán Gabás. Regulation of the transcriptional activity of the CRMP-2 gene in neuroblastoma cells.
Director: Ana Rouzaut. area of Biochemistry and Molecular Biology.

Mikel Valgañón Petrizán. Analysis of TP53 and characterisation Genetics and molecular characterisation of 54 patients with stage III and IV chronic lymphocytic leukaemia treated first line with fludarabine.
Directors: Mª Dolores Odero de Dios and Mª José Calasanz Abínzano. area de Genetics.

Icíar Paula López García. Analysis of gene expression in white adipose tissue of rats fed with a high-fat per diem expenses .
DirectorCarlos de Miguel Vázquez. area of Biochemistry and Molecular Biology.

Idoya Zazpe Cenoz. profile glioblastoma genetics and analysis of deletions in chromosomes 10q and 9p.
DirectorJavier Sáez Castresana. area de Genetics.

Eduardo Ansorena Artieda. Study of the effect of S-Adenosylmethionine on liver cell apoptosis.
Director: María Iraburu Elizalde. area of Biochemistry and Molecular Biology.

Silvia Cenoz Zubillaga. Analysis of the endogenous activity of pigmented epithelium-derived factor (PEDF) in tumour cell lines.
DirectorLuis Alberto Pérez Mediavilla. area of Biochemistry and Molecular Biology.

Carlos Cruchaga Gómez. A new strategy to combat HIV resistance to nucleoside analogues: inhibitors of phosphorolysis catalysed by viral reverse transcriptase.
DirectorJuan José Martínez Irujo. area of Biochemistry and Molecular Biology.

• Curso 2000-2001
   
  José Ignacio Martín Subero. Development of the multicolor FICTION technique. Applications to the diagnosis and research of malignant lymphomas. Doctorado europeo. Premio Extraordinario de Doctorado.
  Directores: Reiner Siebert (Instituts für Humangenetik, Universitätsklinikums Schleswig-Holstein, Kiel) y Mª José Calasanz Abínzano. Área de Genética.
   
  Eduardo Domingo de Miguel. Efecto de un péptido inmunomodulador y de lipopolisacáridos de bacterias del subgrupo a-2 de la clase proteobacteria sobre monocitos humanos. Regulación de la producción de óxido nítrico.
  Directora: Natalia López Moratalla. Área de Bioquímica y Biología Molecular.
   
  Mª Teresa Sesma Pascual. Expresión diferencial de genes en monocitos.
  Director: Carlos de Miguel Vázquez. Área de Bioquímica y Biología Molecular.
   
  Xing Fan. Genetic profile, co-alterations of PTEN, p16 and CDK4 genes, and therapeutic role of PTEN in human astrocytomas. Doctorado europeo.
  Director: Javier Sáez Castresana. Área de Genética.
              
  Curso 2001-2002
   
  Guillermo García del Barrio. Desarrollo de nuevos sistemas farmacéuticos para la transferencia génica al músculo.
  Directores: Juan Manuel Irache Garreta y Francisco Javier Novo Villaverde. Área de Genética.
   
  Marta Varela Rey. Estudio del efecto antifibrogénico del TNF-a en células estelares hepáticas.
  Directora: María Iraburu Elizalde. Área de Bioquímica y Biología Molecular.
   
  Mª Dolores Parra Astorgano. Caracterización metodológica del test de aliento con 2-ceto[1-13C] isocaproato para su aplicación en el estudio de la función mitocondrial.
  Director: Álvaro González Hernández. Área de Bioquímica y Biología Molecular.
   
  Miguel Ángel Zaratiegui Biurrun. Desarrollo de vectores virales adenoasociados para transferencia génica al músculo y su aplicación en distintos modelos biológicos.
  Director: Francisco Javier Novo Villaverde. Área de Genética
   
  Rafael Hernández Mañú. Análisis del promotor del gen de la P44mapk humana.
  Director: Carlos de Miguel Vázquez. Área de Bioquímica y Biología Molecular.
   
  Cristina Montiel Duarte. Estudio de la apoptosis inducida por la MDMA en células hepáticas de rata.
  Directora: María Iraburu Elizalde. Área de Bioquímica y Biología Molecular.
   
  Beatriz Pelacho Samper. Relación entre los sistemas neuroendocrino e inmunitario y la piel.
  Directora: Mª Jesús López Zabalza. Área de Bioquímica y Biología Molecular.
   
  Leticia Odriozola Moncayola. Resistencia de la transcriptasa inversa del HIV-1 al AZT. Papel de la fosforolisis.
  Director: Juan José Martínez Irujo. Área de Bioquímica y Biología Molecular.
              
  Curso 2002-2003
   
  Sergio Portal Núñez. Desarrollo de inhibidores peptídicos de la NS3a del virus de la hepatitis C (VHC).
  Directores: Marina García Delgado y Francisco Borrás Cuesta. Área de Genética.
   
  Xabier Agirre Ena. Análisis de mutaciones, estado de metilación del promotor y deleción del gen TP53 en la leucemia aguda linfoblástica. Premio Extraordinario de Doctorado.
  Directores: José Luis Vizmanos Pérez y Marina García Delgado. Área de Genética.
   
  Iñígo Izal Azcárate. Estudio de la actividad biológica del factor derivado del epitelio pigmentado (PEDF).
  Director: Luis Alberto Pérez Mediavilla. Área de Bioquímica y Biología Molecular.
   
  Esther Andión Ibáñez. Estudio del valor pronóstico y predictivo de la resistencia frente a agentes alquilantes de los genes MGMT y TP53 en una serie de astrocitomas de alto grado.
  Directores: Jesús García Foncillas (CUN) y José Luis Vizmanos Pérez. Área de Genética.
   
  Curso 2003-2004
   
  Idoya Lahortiga Ayerra. Molecular characterization of chromosomal rearrangements in acute myeloid leucemia. Analysis of the regions 1p36, 11p15, 12p13 y 16p13. Curso 2003-2004. Doctorado europeo. Premio Extraordinario de Doctorado.
  Directoras: Mª Dolores Odero de Dios y Mª José Calasanz Abínzano. Área de Genética.
   
  Jorge Muñoz Aranda. Análisis de deleciones homocigóticas, metilación de promotores y daño genómico en tumores del sistema nervioso.
  Director: Javier Sáez Castresana. Área de Genética.
   
  Alberto Monasterio Asteinza. Caracterización de las Dnasas activadas en la estimulación y en la apoptosis de monocitos.
  Director: Juan José Martínez Irujo. Área de Bioquímica y Biología Molecular.
   
  Mª del Mar Inda Pérez. Different genetic profiles determined in supratentorial PNET, medulloblastomas, and neuroblastic tumors. Doctorado europeo. Premio Extraordinario de Doctorado.
  Director: Javier Sáez Castresana. Área de Genética
   
  Cristina Natal Gorgojo. Influencia de la matriz extracelular en la apoptosis del sistema monocito/macrófago.
  Directora: Mª Jesús López Zabalza. Área de Bioquímica y Biología Molecular.
   
  Verónica Fernández Ruiz. Efecto del óxido nítrico en la diferenciación de los monocitos de sangre periférica a células dendríticas.
  Director: Álvaro González Hernández. Área de Bioquímica y Biología Molecular.