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2018/2019 academic year
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2017/2018 academic year
David Navarro Herrera. "development, validation and implementation of a modelin C. elegans for the identification of bioactive compounds in obesity-related processes". Director José Luis Vizmanos Pérez. Date: 14 December 2017
Estefanía Rojo Bustamante. "Characterization of the neuroprotective effect of the monoacylglycerol lipase inhibition using in vitro and in vivo models of Parkinson's disease". Director: Marisol Aymerich Soler. Date: 13 December 2017
Laura Eder Azanza. "Analysis of new genetic alterations in BCR-ABL1 negative myeloproliferative neoplasms. developmentof an experimental modelof subject1 and subject2 mutations in CALR in Caernohabditis elegans". Director José Luis Vizmanos Pérez. Date: 1 December 2017.
Álvaro Pejenaute Martínez de Lizarrondo:"Potential role of NADPH oxidase 5 (NOX5) in arterial hypertensionDevelopment of a new animal mode and a recombinant adenovirus". Director By: Guillermo Zalba. Date: 24 November 2017.
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2016/2017 academic year
Ricardo García López: "The role of Tox3 and histone deacetylase inhibitors in embryonal tumours". Directors: Javier Sáez Castresana and Xin Fan (University of Michigan). Date: 31 July 2017.
Beatriz Vera Cano: "Oncolytic adenoviruses as a therapeutic strategy for central nervous system tumours". Directors Marta María Alonso Roldán and Javier Sáez Castresana. Date: 13 March 2017.
Javier de la Rosa Fernández-Pacheco: Synergistic study of the drugs APR-246, DZ-Nep, panobinostat and temozolamide as pharmacological treatment in glioblastoma. Directors: Javier Sáez Castresana and Miguel Ángel IdoateGastearena Date 11 November 2016.
Maider Varela Guruceaga: Effect of hypoxia on caveolin-1 expression, caveolae structure and insulinsignaling. Directors: Carlos de Miguel Vázquez and Fermín Milagro Yoldi. Date: 12 December 2016
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Academic year 2014 / 2015
Carmen Pérez de Ciriza Villacampa. Evaluation of circulating osteoprotegerin as a new biomarker in the metabolic syndrome: cardiovascular risk assessment, analytical factors and circulating sources.
Director: Nerea Varo. areade Biochemistry
Marina Ruiz de Galarreta Martínez. Regulation of liver fibrogenesis by UPR and COMP protein..
Director: Maria Iraburu. areaby Biochemistry .
Sara Palacios Ortega. Regulation of Caveolin-1 expression and activation during adipogenesis, and its relationship with insulin signalling. Effect of TNF-alpha and glucose..
Directors: Carlos de Miguel and Fermín Milagro.
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2013 / 2014 academic year
Marta Fernández Mercado. Characterisation Geneticsof patients with myelodysplastic syndrome and normal karyotype. Prevalence and functional analysis of ASXL1 gene mutations. doctorateEuropean.
Directors: Mª Dolores Odero de Dios and Jacqueline Boultwood (University of Oxford). areade Genetics.Mikhail Shugay. Computational analysis of gene fusions in cancer.
DirectorFrancisco Javier Novo Villaverde. areade Genetics.Xabier Cortés Lavaud. Contribution of the GATA2 transcription factor to the development and progression of myeloid malignancies.
Director: Mª Dolores Odero de Dios. areade Genetics.Marta Zamarbide González. Study of the neurodegenerative mechanisms related to endoplasmic reticulum stress and free fatty acid receptors in Alzheimer's disease.
Directors: Alberto Pérez Mediavilla and Rafael Franco Fernández.
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2012 / 2013 academic year
Diana Fernández Suárez. Anatomical-functional study of the external globus pallidus and assessmentof the neuroprotective effect of the endocannabinoid system in animal models of Parkinson's disease.
Directors: Marisol Aymerich Soler and Rafael Franco. areaof Biochemistry and Molecular Biology.
Iñigo Ortiz de Mendibil Ayuso. Strategy for the identification and functional characterisation of new chromosomal translocations in cancer.
DirectorFrancisco Javier Novo Villaverde. areaof Genetics.
Laura Montero Barreras. Oxidative stress and telomere shortening in patients with metabolic syndrome: role of NADPH oxidase.
DirectorGuillermo Zalba Goñi. areaof Biochemistry and Molecular Biology.
Elisa Mª Salas Cintora. Genetic mechanisms of activation of the JAK2/STAT5 signal transduction pathway in haematological malignancies: identification and characterisation of new target genes.
DirectorFrancisco Javier Novo Villaverde. areade Genetics.
Idoia Blanco Luquin. Analysis of the p53/Mdm2/p14ARF pathway in neuroblastoma and its relationship with chemotherapy.
Directors: Ignacio Encío Martínez and Paula Lázcoz Ripoll (UPNA) and Javier Sáez Castresana. areaof Biochemistry and Molecular Biology.
Ignacio Erquiaga Martínez. Analysis of cytokine receptors in BCR-ABL1 negative chronic myeloproliferative neoplasms.
DirectorJosé Luis Vizmanos Pérez. areade Genetics.
Álvaro Teijeira Sánchez Dendritic cell trafficking through the lymphatic endothelium under inflammation.
Directors: Ana Rouzaut Subirá and Ignacio Melero Bermejo. areaBiochemistry and Molecular Biology.
Elisabeth Salvo Brugarolas Study of cellular and molecular mechanisms involved in NSCLC cell migration induced by TGF-beta.
Director: Ana Rouzaut Subirá. areaBiochemistry and Molecular Biology.
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Academic year 2011 / 2012
Begoña Euba Rementería. Epigenetic analysis of the PIAS family genes and detection of mutations in the TET2 gene in myeloproliferative neoplasms.
Director: Marina García Delgado. areade Genetics.
Mª Pilar Gil Sánchez. Role of FAK in the acantholysis of pemphigus vulgaris in a murine model.
Directors: Agustín España Alonso (CUN) and Mª Jesús López Zabalza. areaof Biochemistry and Molecular Biology.
Miren Maicas Irigaray. Mechanism of expression regulation and functional analysis of the EVI1 gene promoter. awardExtraordinary of doctorate.
Director: Mª Dolores Odero de Dios. areade Genetics.
Mikel Gurrea Rubio. Inhibition of Histone Deacetylase 4 reduces glioblastoma tumour growth in vivo: the role of deacetylases inhibitors and Notch signaling pathway in the treatment of glioblastomas.
Directors: Javier Sáez Castresana and Xing Fan (University of Michigan, Ann Arbor, MI, USA). areade Genetics.
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2010 / 2011 academic year
Paula Aranaz Oroz. Genetic mechanisms of activation of signal transduction pathways in BCR-ABL1-negative chronic myeloproliferative neoplasms.
DirectorJosé Luis Vizmanos Pérez. areade Genetics.
Paula Valentina Schiapparelli Rodríguez. Role of Sonic Hedghog inhibition and characterization of stemness gene expression in neuroblastoma and Ewing sarcoma/PNET. doctorateeuropeo.
Directors: Javier Sáez Castresana and Paula Lázcoz Ripoll (Public University of Navarra). areade Genetics.
Elena Arriazu Ruiz. Characterisation of the response of hepatic stellate cells to amino acid deficiency.
Director: María Iraburu Elizalde. areaof Biochemistry and Molecular Biology.
Ion Cristóbal Yoldi. Role of protein phosphatase 2A (PP2A) and its endogenous inhibitor SET in the developmentof acute myeloid leukaemia. awardExtraordinary of doctorate.
Director: Mª Dolores Odero de Dios. areade Genetics.
Jana Balbuena Delgado. Implication of Side Population tumour stem cells and hypoxia in drug resistance in astrocytoma cell lines.
Directors: Javier Sáez Castresana and Jordi Petriz (Hospital Vall d'Hebron, Barcelona). areade Genetics.
Natalia Suárez Fuentetaja. programs of studyon the function of dendritic cells and their application in cancer immunotherapy.
DirectorÁlvaro González Hernández. areaof Biochemistry and Molecular Biology.
Erik Wolfgang Oliemuller García. Function of collapsin response mediator protein-2 (CRMP-2) in non-small cell lung cancer.
Director: Ana Rouzaut Subirá. areaof Biochemistry and Molecular Biology.
Alicia Zuazo Pérez. New angiogenesis inhibitors that exploit tumour hypoxia for therapy.
Directors: María Font Arellano and Juan José Martínez Irujo. areaof Biochemistry and Molecular Biology.
Leticia Corrales Pecino. Complement activation in non-small cell lung cancer and its effects on tumour progression.
DirectorRubén Pío Osés. areaof Biochemistry and Molecular Biology.
Marta Larráyoz Ilundáin. Functional relevance of VEGF-A and its receptors in lung cancer.
Directors: Jackeline Agorreta Arrazubi (CIMA) and Rubén Pío Osés. areaof Biochemistry and Molecular Biology.
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Academic year 2009 / 2010
Maider Prétel Irazábal. Role of HER isoforms and mTOR in the acantholysis of pemphigus vulgaris in a murine model.
Directors: Mª Jesús López Zabalza and Agustín España Alonso (CUN). areaof Biochemistry and Molecular Biology.
Cristina Ormazábal Goicoechea. Analysis of alterations in protein-coding genes with tyrosine kinase activity of the PDGFR and JAK families in BCR-ABL1-negative chronic myeloproliferative neoplasms.
DirectorJosé Luis Vizmanos Pérez. areade Genetics.
Teresa Mòdol Betriu. Effects of inflammatory mediators on monocytes and hepatic stellate cells.
Director: Mª Jesús López Zabalza. areaof Biochemistry and Molecular Biology.
Carmen Vicente Vázquez. Role of the transcription factors GATA2 and MYB in acute myeloid leukaemia. doctorateEuropean.
Director: Mª Dolores Odero de Dios. areaof Genetics.
Ana Gómez Ruiz. Caveolin expression in skeletal muscle and adipocytes of white adipose tissue from rats fed with a high-fat hypercaloric per diem expenses. Relationship with insulin signalling.
Directors: Carlos de Miguel Vázquez and Fermín Milagro Yoldi. areaof Biochemistry and Molecular Biology.
Patricia Restituto Aranguíbel. Study of the CD40/CD40L dyad and its modulation by adiponectin in metabolic syndrome.
Director: Nerea Varo Cenarruzabeitia. areaof Biochemistry and Molecular Biology.
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Academic year 2008 / 2009
Elena Ansó Monclús. Effect on lymphatic endothelium of tumour hypoxia and inhibition of VEGF production by flavonoids.
DirectorJuan José Martínez Irujo. areaof Biochemistry and Molecular Biology.
Monica Enguita Germán. Genetics and biology of medulloblastoma and PNET cell lines: role of CD133 brain tumour stem cell marker. doctorateEuropean.
DirectorJavier Sáez Castresana. areade Genetics.
Ángel Díaz Lagares. Study of the action of nitric oxide on the HLA-G molecule and its ILT2 and ILT4 receptors.
DirectorÁlvaro González Hernández. areaof Biochemistry and Molecular Biology.
Iria Vázquez Urio. Mechanisms of overexpression of the EVI1 gene (3q26) and its role in the leukemic transformation of patients with acute myeloid leukaemia. doctorateEuropean.
Director: Mª Dolores Odero de Dios. areade Genetics.
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Academic year 2007 / 2008
Elisa Garbayo Atienza. design of polymeric vectors for the controlled release of GDNF in animal models of Parkinson's disease. Therapeutic perspectives.
Directors: Marisol Aymerich Soler and Mª José Blanco Prieto. areaof Biochemistry and Molecular Biology.
Aiala Lorente Trigos. Epigenetic inactivation of tumour suppressor genes in astrocytomas. doctorateEuropean.
DirectorJavier Sáez Castresana. areaof Genetics.
Mónica Pérez Manso. Brain circuits involved in Parkinson's disease: thalamo-striatal pathway and expression of vesicular glutamate transporters.
Directors: Marisol Aymerich Soler and José Luis Lanciego Pérez. areaof Biochemistry and Molecular Biology.
Estíbaliz Alegre Martínez. Study of molecules related to immunological tolerance HLA-G and indolamine 2,3-dioxygenase during pregnancy.
DirectorÁlvaro González Hernández. areaof Biochemistry and Molecular Biology.
Miren Marquina Iñarrairaegui. Role of nitric oxide synthase in the acantholysis of Pemphigus vulgaris in a murine model.
Directors: Mª Jesús López Zabalza and Agustín España Alonso (CUN). areaof Biochemistry and Molecular Biology.
Eva Martínez García. Study of the effect of repetitive exhibitionto acute doses of nicotine on human bronchial epithelium cells.
Director: Ana Rouzaut Subirá. areaof Biochemistry and Molecular Biology.
Mª Pilar Pérez de Obanos Martell. Regulation of the fibrogenic activity of hepatic stellate cells by leucine.
Director: María Iraburu Elizalde. areaof Biochemistry and Molecular Biology.
Marta Irigoyen Goñi. Hypoxic microenvironment in tumours: evaluationof its influence on lymphangiogenesis processes.
Director. Ana Rouzaut Subirá. areaof Biochemistry and Molecular Biology.
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2005 / 2006 academic year
Daniel Ajona Martínez-Polo. Expression of factor H in lung cancer and its protective role against the activation of the complement system.
DirectorRubén Pío Osés. areade Biochemistry and Molecular Biology.
Borja Sáez Ochoa. Molecular cytogenetic characterization of chromosomal changes in Multiple Lyeloma. New insights into pathogenesis and diagnosis. doctorateeuropeo.
Directors: Reiner Siebert (Instituts für Humangenetik, Universitätsklinikums Schleswig-Holstein, Kiel) and Mª José Calasanz Abínzano. areade Genetics.
Zafira Castaño Corsino. Function of alpha CP-4 in lung carcinogenesis. assessmentof its possible role as a tumour suppressor gene.
DirectorRubén Pío Osés. areaof Biochemistry and Molecular Biology.
Lorena Fontán Gabás. Regulation of the transcriptional activity of the CRMP-2 gene in neuroblastoma cells.
Director: Ana Rouzaut. areaof Biochemistry and Molecular Biology.
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2004 / 2005 academic year
Mikel Valgañón Petrizán. Analysis of TP53 and characterisation Geneticsand molecular characterisation of 54 patients with stage III and IV chronic lymphocytic leukaemia treated first line with fludarabine.
Directors: Mª Dolores Odero de Dios and Mª José Calasanz Abínzano. areade Genetics.
Icíar Paula López García. Analysis of gene expression in white adipose tissue of rats fed with a high-fat per diem expenses.
DirectorCarlos de Miguel Vázquez. areaof Biochemistry and Molecular Biology.
Idoya Zazpe Cenoz. profile glioblastoma genetics and analysis of deletions in chromosomes 10q and 9p.
DirectorJavier Sáez Castresana. areade Genetics.
Eduardo Ansorena Artieda. Study of the effect of S-Adenosylmethionine on liver cell apoptosis.
Director: María Iraburu Elizalde. areaof Biochemistry and Molecular Biology.
Silvia Cenoz Zubillaga. Analysis of the endogenous activity of pigmented epithelium-derived factor (PEDF) in tumour cell lines.
DirectorLuis Alberto Pérez Mediavilla. areaof Biochemistry and Molecular Biology.
Carlos Cruchaga Gómez. A new strategy to combat HIV resistance to nucleoside analogues: inhibitors of phosphorolysis catalysed by viral reverse transcriptase.
DirectorJuan José Martínez Irujo. areaof Biochemistry and Molecular Biology.
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Previous courses
Curso 2000-2001
José Ignacio Martín Subero. Development of the multicolor FICTION technique. Applications to the diagnosis and research of malignant lymphomas. Doctorado europeo. Premio Extraordinario de Doctorado.
Directores: Reiner Siebert (Instituts für Humangenetik, Universitätsklinikums Schleswig-Holstein, Kiel) y Mª José Calasanz Abínzano. Área de Genética.
Eduardo Domingo de Miguel. Efecto de un péptido inmunomodulador y de lipopolisacáridos de bacterias del subgrupo a-2 de la clase proteobacteria sobre monocitos humanos. Regulación de la producción de óxido nítrico.
Directora: Natalia López Moratalla. Área de Bioquímica y Biología Molecular.
Mª Teresa Sesma Pascual. Expresión diferencial de genes en monocitos.
Director: Carlos de Miguel Vázquez. Área de Bioquímica y Biología Molecular.
Xing Fan. Genetic profile, co-alterations of PTEN, p16 and CDK4 genes, and therapeutic role of PTEN in human astrocytomas. Doctorado europeo.
Director: Javier Sáez Castresana. Área de Genética.
Curso 2001-2002
Guillermo García del Barrio. Desarrollo de nuevos sistemas farmacéuticos para la transferencia génica al músculo.
Directores: Juan Manuel Irache Garreta y Francisco Javier Novo Villaverde. Área de Genética.
Marta Varela Rey. Estudio del efecto antifibrogénico del TNF-a en células estelares hepáticas.
Directora: María Iraburu Elizalde. Área de Bioquímica y Biología Molecular.
Mª Dolores Parra Astorgano. Caracterización metodológica del test de aliento con 2-ceto[1-13C] isocaproato para su aplicación en el estudio de la función mitocondrial.
Director: Álvaro González Hernández. Área de Bioquímica y Biología Molecular.
Miguel Ángel Zaratiegui Biurrun. Desarrollo de vectores virales adenoasociados para transferencia génica al músculo y su aplicación en distintos modelos biológicos.
Director: Francisco Javier Novo Villaverde. Área de Genética
Rafael Hernández Mañú. Análisis del promotor del gen de la P44mapk humana.
Director: Carlos de Miguel Vázquez. Área de Bioquímica y Biología Molecular.
Cristina Montiel Duarte. Estudio de la apoptosis inducida por la MDMA en células hepáticas de rata.
Directora: María Iraburu Elizalde. Área de Bioquímica y Biología Molecular.
Beatriz Pelacho Samper. Relación entre los sistemas neuroendocrino e inmunitario y la piel.
Directora: Mª Jesús López Zabalza. Área de Bioquímica y Biología Molecular.
Leticia Odriozola Moncayola. Resistencia de la transcriptasa inversa del HIV-1 al AZT. Papel de la fosforolisis.
Director: Juan José Martínez Irujo. Área de Bioquímica y Biología Molecular.
Curso 2002-2003
Sergio Portal Núñez. Desarrollo de inhibidores peptídicos de la NS3a del virus de la hepatitis C (VHC).
Directores: Marina García Delgado y Francisco Borrás Cuesta. Área de Genética.
Xabier Agirre Ena. Análisis de mutaciones, estado de metilación del promotor y deleción del gen TP53 en la leucemia aguda linfoblástica. Premio Extraordinario de Doctorado.
Directores: José Luis Vizmanos Pérez y Marina García Delgado. Área de Genética.
Iñígo Izal Azcárate. Estudio de la actividad biológica del factor derivado del epitelio pigmentado (PEDF).
Director: Luis Alberto Pérez Mediavilla. Área de Bioquímica y Biología Molecular.
Esther Andión Ibáñez. Estudio del valor pronóstico y predictivo de la resistencia frente a agentes alquilantes de los genes MGMT y TP53 en una serie de astrocitomas de alto grado.
Directores: Jesús García Foncillas (CUN) y José Luis Vizmanos Pérez. Área de Genética.
Curso 2003-2004
Idoya Lahortiga Ayerra. Molecular characterization of chromosomal rearrangements in acute myeloid leucemia. Analysis of the regions 1p36, 11p15, 12p13 y 16p13. Curso 2003-2004. Doctorado europeo. Premio Extraordinario de Doctorado.
Directoras: Mª Dolores Odero de Dios y Mª José Calasanz Abínzano. Área de Genética.
Jorge Muñoz Aranda. Análisis de deleciones homocigóticas, metilación de promotores y daño genómico en tumores del sistema nervioso.
Director: Javier Sáez Castresana. Área de Genética.
Alberto Monasterio Asteinza. Caracterización de las Dnasas activadas en la estimulación y en la apoptosis de monocitos.
Director: Juan José Martínez Irujo. Área de Bioquímica y Biología Molecular.
Mª del Mar Inda Pérez. Different genetic profiles determined in supratentorial PNET, medulloblastomas, and neuroblastic tumors. Doctorado europeo. Premio Extraordinario de Doctorado.
Director: Javier Sáez Castresana. Área de Genética
Cristina Natal Gorgojo. Influencia de la matriz extracelular en la apoptosis del sistema monocito/macrófago.
Directora: Mª Jesús López Zabalza. Área de Bioquímica y Biología Molecular.
Verónica Fernández Ruiz. Efecto del óxido nítrico en la diferenciación de los monocitos de sangre periférica a células dendríticas.
Director: Álvaro González Hernández. Área de Bioquímica y Biología Molecular.