research obesity: understanding it to transform it
project
SILENT INFLAMMATION,
AGING AND OMEGA-3
IP: María Jesús Moreno-Aliaga
research center Nutrition, School Pharmacy and Nutrition
Funding: State researchAgency
Unraveling the role of pro-resolving lipid mediators of inflammation and their receptors in obesity-related diseases: new therapeutic approaches for Maresin 1 (RESOLBE)
When we talk about obesity, we tend to think only about excess weight or diet, but not so much about what happens "inside." However, obesity is associated with chronic, silent inflammation that, over time, can damage various organs and facilitate the development diseases. The problem is not only that this inflammation increases, but also that the body loses part of its ability to "resolve" it correctly. Understanding why this system fails with obesity and aging can help prevent diseases such as insulin resistance, fatty liver, or even certain types of cancer, and open up new avenues of treatment based on restoring that balance. This project the therapeutic potential and metabolic actions of a molecule derived from omega-3, called Maresina 1, which financial aid resolve inflammation naturally.
Why does it matter?
"Silent chronic inflammation" is like having a small "flame" that is always burning and can damage our organs. Pro-resolving lipid mediators of inflammation "extinguish" that flame and repair damaged tissue. This project how obesity or aging alter the ability to resolve inflammation and seeks therapeutic strategies to combat it.
project MMP14/GDF15project
AGING AND METABOLISM
IP: Javier Gómez Ambrosi
Endocrinology and Nutrition,Clínica Universidad de Navarra
Funding: Carlos III Health Institute
Beneficiary: IdiSNA
Role of the MMP14/GDF15 axis in obesity-related metabolic alterations and their interaction with age.
Over the years, metabolism changes, increasing the risk of diabetes or fatty liver disease. This research the relationship between the proteins MMP14 and GDF15. While the latter financial aid regulate energy balance, the former may be blocking its beneficial action as we age. Confirming this hypothesis would allow for the design of specific treatments to slow down the metabolic changes associated with obesity and age.
Why does it matter?
Many people feel that their metabolism slows down with age and that it becomes more difficult not to gain weight. It's not just a lack of willpower; this project that there are proteins that act as biological "brakes" that prevent our bodies from burning energy efficiently. Identifying these "blockages" is core topic treating obesity in older adults.
project
THE LINK BETWEEN OBESITY AND CANCER
IP: Pilar Lostao
research center Nutrition, School Pharmacy and Nutrition
Funding: Government of Navarra
Beneficiary: IdiSNA
The GLUT12 glucose transporter as a therapeutic target in obese breast cancer patients (ONCOBEGLUT)
This project how excess weight promotes the growth of breast cancer through the GLUT12 protein. In obese individuals, elevated glucose and insulin levels activate this "gateway" for entrance tumor cells, facilitating their growth. The goal to determine whether blocking this pathway could become a new cancer treatment strategy, especially for obese women.
Why does it matter?
Breast cancer cells need a lot of energy, which comes from glucose. Obesity causes there to be much more glucose available to the tumor. The GLUT12 protein acts as a entrancegateway entrancefor glucose. Blocking this entrance an attempt to deprive the tumor of the "fuel" it needs to grow.
project
THE IMPORTANCE OF MUSCLE
IP: Amaia Rodríguez
Endocrinology and Nutrition, Clínica Universidad de Navarra
Funding: Government of Navarra
Beneficiary: IdiSNA
Involvement of adipokines regulating activin receptor 2B in the development sarcopenic obesity
Not all obese people have the same profile. Some, in addition to accumulating fat, lose muscle mass, which increases fragility and the risk of disease. This phenomenon is known as sarcopenic obesity. The project the chemical "dialogue" between adipose tissue and muscle through shared proteins. Understanding this communication seeks to protect the patient's strength and quality of life while treating excess weight.
Why does it matter?
You can be overweight and still be "malnourished" in terms of muscle. Muscle mass is the engine that burns fat; if the engine is small and weak, losing weight is much more difficult. Maintaining muscle is not a matter of aesthetics, but of metabolic health: it is the organ that best financial aid sugar and inflammation.
project
MICROBIOTA AND POSTBIOTICS
IP: Fermín Milagroand Paula Aranaz
research center Nutrition, School Pharmacy and Nutrition
Funding: Government of Navarre
Postbiotics against obesity and metabolic syndrome. assessment and mechanisms of action involved. (PARABIOTIC-2)
Why does it matter?
We are all familiar with "probiotics" (live bacteria such as those found in yogurt), but the latest development is "postbiotics." These are components of bacteria that, although no longer alive, continue to send healthy signals to our bodies. They are easier to preserve and can be just as powerful in helping our "second brain" (the gut) regulate weight.
Our intestines are home to bacteria that influence metabolic health. Until now, probiotics (live bacteria) have been used, but they do not always work the same way in everyone. This essay studies how specific species of Lactobacillus, in probiotic (live) or postbiotic (inactive) form, can help improve body composition, maintain stable glucose levels, and reduce fat accumulation in the liver. The idea is to take advantage of their benefits without relying on live microorganisms, seeking more stable and safer solutions that help improve problems such as insulin resistance, inflammation, or fatty liver.
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Risk of childhood obesity: Multi-omic prediction in preschoolers.
IP: Santiago Navas
research center Nutrition, School Pharmacy and Nutrition
Beneficiary: IdiSNA
Multi-omic approach to assess the risk of development in preschoolers from the CORALS cohort (OMICORALS)
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Gut health: How peptides protect the intestinal barrier
IP: Victoria Catalán
Endocrinology and Nutrition, Clínica Universidad de Navarra
Beneficiary: IdiSNA
Role of antimicrobial peptides in regulating intestinal barrier integrity and adipose tissue inflammation in the context of obesity and diabetes subject (IDISNA)
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per diem expenses diet and cardiometabolic health: from patron saint to profile
IP: Miguel Ruiz Canelaand Cristina Razquin Burillo
Preventive Medicine and Public Health, School Medicine
Beneficiary: IdiSNA
Proteomic and multi-omic analyses for the prevention of atrial fibrillation recurrence in the essay PREDIMAR: effect of the per diem expenses Mediterranean on changes after one year (Proteo-PREDIMAR).
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Impact of per diem expenses on metabolic health
IP: Maira Bes Rastrollo
Preventive Medicine and Public Health, School Medicine
BETTER4U - Preventing obesity through Biologically and Behaviorally Tailored Interventions for You.
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