The School was born in October 1958, with a Selective Course that included the disciplines of Mathematics, Physics, Chemistry, Geology and Biology.

The first students of the Selective Course were 64. They shared the premises with Schools of Medicine and Nursing in the first phase of the New School (part of the current Research Building), inaugurated that same year.

After Álvaro del Amo, who was the first Dean of the School between 1958 and 1964, the following members occupied the position position: Julio Rodríguez, Full Professor of Crystallography and Mineralogy (1964-1969) and José González Ibeas, Full Professor of Industrial Physics (1969-1971).

Since the University already had several Departments working in different branches of Biology, it was proposed to launch the licentiate degree (only taught in Madrid and Barcelona). The recognition of the programs of study came in 1964.

The 15 students of the first promotion shared classrooms and laboratories with students of Medicine, Nursing and Pharmacy, on the four floors of the "Escuela Nueva" and on the two floors of the adjoining Edificio de Los Castaños.

From the first course the School created 3 itineraries within the licentiate degree: Fundamental Biology, Animal Biology and Plant Biology, which differed in some subjects of the last two courses.

The last month of the course was dedicated to field trips: excursions to different places to observe the landscape, geography, soils, vegetation and fauna in situ. They also collected material for later study in the laboratories.

In 1966, classes in Physical Sciences began. The first graduating class, composed of 9 students, graduated in the 69-70 academic year. In the following years the number of graduates grew issue . So did the number of professors in the Physics section.

Classes were given at the University's headquarters in San Sebastian, then located on Urdaneta Street, and later in Ibaeta. They shared facilities with Tecnun, where they were finally integrated at the end of the 70s.

Rafael Jordana defended in 1968 the first thesis at School (Biology). In Chemistry, Mª Josefina Renedo (1972); in Geology, Ignacio Sánchez-Carpintero (1972); in Physics, Emilio Díaz Calavia (1977); and in Mathematics, Santiago Tejero (1990).

In 1970, the construction of Sciences Building (known as the "Hexagon Building"), designed by Carlos Sobrini, was completed. This expanded the issue of classrooms and laboratories for the use of the four Schools: Science, Medicine, Nursing and Pharmacy.

In 1971, Jesús Vázquez, Full Professor of Cytology and Histology, was appointed Dean of the School . He was for ten years, until 1981, when he was replaced by Professor Rafael Jordana, Full Professor of "Animal Physiology" and "Applied Zoology".

In 1974, Professor Rafael Jordana, Associate Dean then of the School, became position of the department of Zoology and put the instructions for the creation of the Museum of Zoology, erected by the President in 1980. He was its director until his retirement in 2011.

In 1990, the Museum incorporated the collections donated to the University by high school Nuestra Señora del Buen committee de Lecároz. Subsequently, together with the Botanical Herbarium and various donations in the Science Museum.

In 1989, the School launched two new degrees within the high school University of Applied Sciences: "Chemistry Applied" (replacing Technical Assistants of laboratory, which was directed by Dr. Valdés) and "Dietetics and Human Nutrition".

In 1990 Pilar Sesma was appointed dean of School. She served for 15 years, until 2005. She was the first alumna of the School to occupy the position.

She had obtained the Chair in 1983.

In 2016 she received the Gold Medal of the University.

During these years, the Physics high school was launched, which housed the Physics and Mathematics department ; and the Ministry approved the programs of study of doctorate in Physics.

Héctor Mancini was one of its promoters and its director from 1996 to 2010.

In 1992, the IBA (high school of Applied Biology) was established to cover the industry-oriented research , in which all Departments participated. It was replaced by what is now called Research Management Service.

In 1995, "Human Nutrition and Dietetics" was transformed into licentiate degree. It became official in 1998 (we were the first Spanish university to do so). In the 2005-06 academic year, the degree program was attached to the School of Pharmacy.

In 1995, the programs of study of Chemistry became licentiate degree . To teach the second cycle of the degree program new laboratories were necessary, which were built in the extension building of the Science Library.

In the same year, the licentiate degree of second cycle of Biochemistry also began.

In 1998 the Science Museum was inaugurated, which includes several collections of minerals and fossils and the collections of the Botanical Herbarium and the Zoology Museum, which in 1990 had incorporated the collections donated to the University by the high school Nuestra Señora del Buen committee de Lecároz.

Today the Museum is exhibited in showcases distributed throughout the five floors of Hexagon Building, until it has its own headquarters in the new BIOMA Center.

In 2001, the group of Environmental Volunteers was created by the initiative of a group of students from the School of Sciences united by their interest in environmental conservation. At the beginning of the 2009-2010 academic year, the group received a new impetus.

In 2004, the Cima University of Navarra was inaugurated. The participation and contribution of the School, especially in the areas of Biology and Biochemistry , was decisive. And it continues to be so: a very high percentage of our alumni work in their research.

In addition, many of the Cima researchers teach class at School.

Ignacio López-Goñi was appointed Dean in 2005. He had studied the licentiate degree in Biology at the School and had obtained the award Extraordinary doctorate in 1989. After several postdoctoral stays in the USA, he had joined the department as a professor at Microbiology and Parasitology in 1992.

In 2009 he obtained the accreditation as Full Professor of Microbiology.

He is currently the director of the Science Museum of the University of Navarra.

In 2005 was founded the laboratory Integrated Environmental Quality (LICA), formed by professors of the department of Chemistry and Soil Science who develop activities of teaching, research and attendance technique in the environmental field.

In 2008 the School launched the Master's Degree at research Biomedical.

In 2009, with the adaptation to the "Bologna plan", the School began to offer the new Degrees in Biology, Biochemistry and Chemistry. The offer professor of Degree of the School was completed in the 2014/15 academic year with the Degree in Environmental Sciences.

In 2014 he was appointed Dean Luis Montuenga, Full Professor of Cell Biology at Schools of Science and Medicine, and researcher senior at Cima University of Navarra.

In 2016, the First José María Albareda Lecture was held, an initiative of the Chair Timac Agro-University of Navarra. The first guest was Avelino Corma, award Príncipe de Asturias de research Científica y Técnica in 2014.

In 2017, School launched the 'Women for Science and Technology' initiative. Formed by female professors, researchers and students, it seeks to support female students who wish to pursue scientific careers, and to make the presence of women in science visible.

In 2019, the School began teaching the Master's Degree in Computational Methods in Science.

In January 2020, the Biodiversity and Environment Institute was created by School to address questions core topic on nature and the future of the planet. The center is composed of more than 60 specialists from different areas of research.

Since its inception, the School has been committed to the scientific knowledge dissemination as one of its basic pillars. Now, together with the Science Museum, it organizes various activities, especially aimed at school students.