department of Biochemistry and Genetics

Objectives:
Includes resources from Bioinformatics, Genetic Analysis Service and Biochemistry Clinical Service from Clínica Universidad de Navarra.

Research groups:

• Analysis of the genetic mechanisms causing myeloproliferative neoplasms. Analysis of new genetic alterations causing chronic myeloproliferative neoplasms. Analysis of the regulatory mechanisms of the JAK-STAT pathway and the genes regulated by it. Loss-of-function alterations in inhibitory genes of the JAK-STAT pathway. Mechanisms governing training and oncogenic potential of chromosomal translocations.
  - contact: José Luis Vizmanos Pérez

• Regulation of liver fibrosis. UPR as a modulator of liver fibrosis.
  - contact: María Iraburu Elizalde

• Genetics of Acute Myeloid Leukemia (AML). Study of protein phosphatase PP2A in acute myeloid leukemia transformation and its possible role as a therapeutic target in cancer. Role of EVI1 and GATA2 as transcription factors.
  - contact: María Dolores Odero de Dios
  
• Gene regulation and obesity: Epigenetic regulation of Caveolin-1 and its relationship with insulin signaling.
  - contact: Carlos de Miguel Vázquez
  
• Biology, Genetics and experimental treatment of brain tumors. Cell and Molecular Biology of glioblastoma, medulloblastoma and neuroblastoma. Genetics characterization of tumor stem cells of brain tumors. Inhibitory treatments of brain tumor stem cells.
  - contact: Javier Sáez de Castresana
  
• Characterization of the role of oxidative stress in vascular pathophysiology: NADPH oxidase family. Molecular and cellular mechanisms of oxidative stress in cardiovascular pathophysiology in the metabolic syndrome. Characterization of the role of NADPH oxidase 5 in vascular pathophysiology.
  - contact: Guillermo Zalba Goñi
  
• Cardiovascular risk markers. Inflammation markers in cardiovascular risk and atherosclerosis. Osteoporosis markers. Inflammation in chronic obstructive pulmonary disease.
  - contact: Nerea Varo Cenarruzabeitia
  
• Biochemical markers of disease: Inflammation and cardiovascular risk. Immunotolerance.
  - contact: Álvaro González Hernández
  
• Molecular biomarkers in lung cancer. Splicing alterations. Role of the complement system
  - contact: Rubén Pío Osés
  
• Tumor microenvironment. Adhesion of dendritic and tumor cells to the lymphatic endothelium.
  - contact: Ana Rouzaut Subirá
  
• Cellular and molecular neuropharmacology. Neuroprotection in Parkinson's disease. Activity in the basal ganglia.
  - contact: Marisol Aymerich Soler