department of Biochemistry and Genetics

Objectives:
Includes resources from Bioinformatics, Genetic Analysis Service and Biochemistry Clinical Service from Clínica Universidad de Navarra.

Research groups:

• Analysis of the genetic mechanisms causing myeloproliferative neoplasms. Analysis of new genetic alterations causing chronic myeloproliferative neoplasms. Analysis of the regulatory mechanisms of the JAK-STAT pathway and the genes regulated by it. Alterations with loss of function in genes inhibiting the JAK-STAT pathway. Mechanisms governing the training and oncogenic potential of chromosomal translocations.
  - contact: José Luis Vizmanos Pérez

• Regulation of liver fibrosis. The UPR as a modulator of liver fibrosis.
  - contact: María Iraburu Elizalde

• Genetics of Acute Myeloid Leukaemia (AML). Study of protein phosphatase PP2A in the transformation of acute myeloid leukaemia and its possible role as a therapeutic target in cancer. Role of EVI1 and GATA2 as transcription factors.
  - contact: María Dolores Odero de Dios
   
• Gene regulation and obesity: Epigenetic regulation of Caveolin-1 and its relationship with insulin signalling.
  - contact: Carlos de Miguel Vázquez
   
• Biology, Genetics and experimental treatment of brain tumours. Cell and Molecular Biology of glioblastoma, medulloblastoma and neuroblastoma. Characterisation Genetics of brain tumour stem cells. Inhibitory treatments of brain tumour stem cells.
  - contact: Javier Sáez de Castresana
   
• Characterisation of the role of oxidative stress in vascular physiopathology: NADPH oxidase family. Molecular and cellular mechanisms of oxidative stress in cardiovascular physiopathology in the metabolic syndrome. Characterisation of the role of NADPH oxidase 5 in vascular physiopathology.
  - contact: Guillermo Zalba Goñi
   
• Cardiovascular risk markers. Inflammation markers in cardiovascular risk and atherosclerosis. Osteoporosis markers. Inflammation in chronic obstructive pulmonary disease.
  - contact: Nerea Varo Cenarruzabeitia
   
• Biochemical markers of disease: Inflammation and cardiovascular risk. Immunotolerance.
  - contact: Álvaro González Hernández
   
• Molecular biomarkers in lung cancer. Splicing alterations. Role of the complement system
  - contact: Rubén Pío Osés
   
• Tumour microenvironment. Adhesion of dendritic and tumour cells to the lymphatic endothelium.
  - contact: Ana Rouzaut Subirá
   
• Cellular and molecular neuropharmacology. Neuroprotection in Parkinson's disease. Activity in the basal ganglia.
  - contact: Marisol Aymerich Soler