Doctors Luis Montuenga and Rubén Pío, from the area Oncology Department at CIMA, have collaborated in a research led by scientists from the Spanish National Cancer Research Center (CNIO) and Japanese colleagues. They have discovered one of the most frequently mutated genes in lung cancer. The so-called BRG1 is mutated in 25% of the tumors derived from cell lines that the scientists studied. BRG1 is a protein that modifies the structure of chromosomes and makes regions of our genome more or less readable by the cellular machinery. It is thought that BRG1 can regulate gene expression and, for example, activate some genes that protect us against cancer by acting as a tumor suppressor. The finding has been published in the scientific journal Human Mutation and opens a new field to the research of lung cancer, the most deadly cancer in Spain.