Precision medicine advances in proton therapy to reduce toxicity

Having established itself as one of the treatments of choice for complex tumors, proton therapy continues to advance in precision medicine. A team multidisciplinary from the Cancer Center Clínica Universidad de Navarra is developing a method to quantify the radiation dose deposited in the circulating blood during tumor treatment and thus reduce tumor toxicity. partnership The first results have been presented in an oral communication at the congress World Proton Therapy Conference(PTCOG 61) held in Madrid with the support of the Cancer Center Clinica Universidad de Navarra and Quirónsalud.

The study involves 25 patients and demonstrates that a personalized approach can be used to plan and administer the dose specifically for each patient. One of the main advantages of proton therapy over conventional radiotherapy is its ability to more precisely target the radiation beam to the tumor, reducing adverse effects on adjacent healthy tissues. With this method, it will be possible to further customize the treatment by studying the vascular structure containing the patient's circulating blood to adjust the dose and direction of the beam.

“Other programs of study larger organs, such as the kidney, as the target organ. In this case, we have studied the vasculature because it has been observed that the dose can affect blood cells and induce undesirable effects, such as lymphopenia (a condition in which the blood lacks sufficient lymphocytes). Thus, the blood vessels surrounding the tumor become another parameter to consider when determining treatment, with the goal minimizing toxicity as much as possible,” notes Marina García, a biomedical engineer working thesis her thesis the department Physics and Applied Mathematics at the School of Science at the University of Navarra.

To do this, parameters such as blood vessels, their contours, and blood flow will be analyzed , along with technical aspects such as the temporal structure of submission , the energy level, and the start and end times of the treatment field. “There are cases, depending on the tumor’s location—such as in the neck region—where it is practically impossible to avoid major blood vessels. But there are others where you can slightly divert the beam and achieve that improvement,” adds Dr. Javier Burguete, Full Professor Applied Physics at the School of Science.

Application in the internship clinic

The ultimate aim of this project is to improve the clinical internship in radiation oncology by development of algorithms that allow the incorporation of circulating blood as an organ especially decisive in the immunity of patients into radiotherapy planners.

"Blood has been the great forgotten of human tissues to be protected from radiation. The availability of protons and photons allows us to study how to protect patients' immunotherapy through dosimetric planning", commented Dr. Felipe Calvo, Full Professor of Radiation Oncology, researcher main project and director scientific of the Proton Therapy Unit of the Cancer Center Clínica Universidad de Navarra.

The research remains active and the next steps will be to study the clinical implications through blood tests (biomarkers) to establish the correlation of blood doses and how the blood has been damaged.