The 3B5H10 antibody detects toxic species implicated in Huntington's disease. This is the conclusion of a work by Dr. Montse Arrasate, researcher at research center Applied Medicine (CIMA) of the University of Navarra, conducted at theGladstone Institutes of the University of California, San Francisco, at partnership with Steven Finkbeiner.

In Huntington's disease, as in other neurodegenerative diseases, the most important pathological markers are abnormal protein aggregation and selective degeneration of neuronal populations. "One of the unfinished business in the field is to determine which toxic species causes the degeneration. Our work has shown that the 3B5H10 antibody detects toxic species implicated in Huntington's disease. This new antibody recognizes monomers and, probably, small oligomers that predict neuronal death," explains Dr. Arrasate.